针灸科
多囊卵巢
代谢组学
柠檬酸循环
糖异生
医学
脂质代谢
内科学
内分泌学
代谢途径
药理学
新陈代谢
生物信息学
肥胖
化学
生物
胰岛素抵抗
病理
替代医学
作者
Nan Yang,Ke Ma,Weidong Liu,Ning Zhang,Zhouhua Shi,Jian Ren,Weiqing Xu,Yuqiu Li,Riliang Su,Yanbo Liang,Shijun Wang,Xiuyang Li
摘要
Abstract Polycystic ovary syndrome (PCOS) is a common endocrine syndrome, and obesity is the most common clinical manifestation. Acupuncture is effective in treating PCOS, but the differences in the biological mechanisms of acupuncture therapy and Western medicine treatment have not been determined. Thus, the purpose of this study was to find glucose metabolism–related pathways in acupuncture treatment and differentiate them from Western medical treatment. Sixty patients with PCOS‐related obesity were randomly distributed into three groups: patients receiving (1) acupuncture treatment alone, (2) conventional Western medicine treatment, and (3) acupuncture combined with Western medicine treatment. A targeted metabolomics approach was used to identify small molecules and metabolites related to glucose metabolism in the serum of each group, and ultra‐high‐performance liquid chromatography–tandem mass spectrometry was used to analyze different metabolic fractions. The results showed acupuncture treatment modulates the activity of citric and succinic acids in the tricarboxylic acid cycle, regulates glycolytic and gluconeogenesis pathways, and improves the levels of sex hormones and energy metabolism. The intervention effects on the metabolic pathways were different between patients receiving combination therapy and patients receiving acupuncture therapy alone, suggesting that the dominant modulatory effect of Western drugs may largely conceal the efficacy of acupuncture intervention.
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