分子印迹
分子识别
纳米技术
金属有机骨架
分子印迹聚合物
印记(心理学)
跟踪(心理语言学)
检出限
分析物
材料科学
计算机科学
化学
选择性
分子
催化作用
色谱法
吸附
物理化学
生物化学
语言学
哲学
有机化学
基因
作者
Hui Min,Zongsu Han,Tiankai Sun,Kunyu Wang,Jingyi Xu,Peiyu Yao,Sihai Yang⧫,Peng Cheng,Wei Shi
标识
DOI:10.1007/s11426-023-1822-6
摘要
Accommodating target analytes within the pores of metal-organic frameworks (MOFs) to improve the sensing performance is an important but challenging task. Here, we report a novel molecular imprinting strategy to create target recognition sites in a tailored multicomponent MOF with the inter-ligand synergistic antenna effect to lanthanide ions, enabling selective recognition of trace biomarkers, which is critical to the early diagnosis of age-related diseases in blood samples with high sensitivity and ultralow limit of detection (LOD) of 69 nmol L−1. Compared with MOF-based sensors without imprinted recognition sites, the significantly enhanced sensing performance (both sensitivity and LOD) was attributed to a dynamic-static coupled sensing mechanism: the dynamic interactions involve concentrating the trace biomarkers at the imprinted recognition sites to enhance the sensing performance at ultralow concentration, and the static interactions are derived from electron/energy exchange between the molecularly imprinted MOF and the biomarker to govern the sensing performance. This work establishes a new molecular imprinting strategy to attain advanced materials for sensing trace bio-analytes.
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