KDM6A/MMP-3 epigenetic axis governs macrophage senescence after spinal cord injury for mediating the regenerative niche to promote neurological repair

Our findings elucidate the KDM6A/MMP-3 epigenetic regulatory axis, which governs macrophage senescence and creates an inhibitory microenvironment for regeneration after SCI. Targeting this pathway promotes angiogenesis and facilitates neural repair, highlighting its potential as a therapeutic target for improving functional recovery after SCI.