Zeta电位
赫拉
盐酸阿霉素
固体脂质纳米粒
细胞毒性
阿霉素
傅里叶变换红外光谱
粒径
纳米颗粒
化学
毒品携带者
材料科学
核化学
药理学
药物输送
化疗
纳米技术
有机化学
体外
化学工程
医学
生物化学
物理化学
外科
工程类
作者
Sooho Yeo,Huiqiang Wu,Il Yoon,Woo Kyoung Lee,Sung Joo Hwang
标识
DOI:10.1016/j.ijpharm.2024.124048
摘要
Doxorubicin hydrochloride (DOX) is an anticancer agent used in cancer chemotherapy. The purpose of this study was to design nanostructured lipid carriers (NLCs) of DOX as smart chemotherapy to improve its photostability and anticancer efficacy. The characteristics of DOX and DOX-loaded NLCs were investigated using UV-Vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, particle size, and zeta potential study. The cytotoxicity of DOX was evaluated against three cancer cell lines (HeLa, A549, and CT-26). The particle size and zeta potential were in the range 58.45-94.08 nm and -5.80 mV - -18.27 mV, respectively. The chemical interactions, particularly hydrogen bonding and van der Waals forces, between DOX and the main components of NLCs was confirmed by FTIR. NLCs showed the sustained release profile of DOX. The photostability results revealed that the NLC system improved the photostability of DOX. Cytotoxicity results using the three cell lines showed that all formulations improved the anticancer efficacy of free DOX, and the efficacy was dependent on cell type and particle size. These results suggest that DOX-loaded NLCs are promising chemotherapeutic agents for cancer treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI