Pharmacognostic, Phytochemical, Ethnobotanical, and Pharmacological Significance of Silybum marianum (Milk Thistle) – A Comprehensive Review

Abstract: Milk thistle seeds contain silymarin, a powerful hepatoprotective compound known to shield liver cells from toxins, increase glutathione levels, and promote cell regeneration. Silybin, one of the key components of silymarin, is highly valued by herbalists due to its minimal side effects. Silymarin is ubiquitously distributed across diverse geographic regions, encompassing Europe, Africa, Asia, Australia, North and South America, India, and China. Silymarin comprises an array of compounds, specifically silydianin, isosilybin A, isosilybin B, silybin A, and silydianin flavonoids. Its pharmacological applications are multifaceted, including antidiabetic, hepatoprotective, hypocholesterolemic, antihypertensive, anti-inflammatory, anticancer, and antioxidant properties. Milk thistle seeds additionally exhibit anti-spasmodic, neuroprotective, antiviral, immunomodulant, and cardioprotective characteristics. They can even enhance milk secretion and help treat uterine disorders. Such an in-depth inquiry is poised to facilitate the meticulous assessment by researchers of its efficacy in therapeutic applications. Additionally, silymarin exhibits changes in cellular transporter, P-glycoprotein, as well as estrogenic and nuclear receptors. It also impedes apoptosis and follicular development during in vitro fertilization, making it a promising option in complementary medicine. This documented evidence is useful in safeguarding vital organs against an array of maladies, encompassing cancer, in vitro fertilization, hepatotoxicity, nephrotoxicity, viral hepatitis challenges, neurotoxicity, depressive disorders, and pulmonary and prostate disorders. This scholarly article undertakes a comprehensive exploration of the pharmacognostic, morphological, ethnobotanical, and pharmacological importance of Silybum marianum.