Supported-Pd catalyzed carbonylative synthesis of phthalimides and isoindolinones using Oxalic acid as in situ CO surrogate with 2-iodobenzamides and 2-iodobenzylanilines in ppm-level catalyst loading

Polystyrene supported palladium ([email protected]) nanoparticles (NPs) catalyzed intramolecular aminocarbonylation of 2-iodobenzamides and 2-iodobenzylanilines using bench stable Oxalic acid as in situ CO source for the synthesis of phthalimides and isoindolin-1-one is described. Low catalyst loadings (0.2 mol%, 2000 ppm Pd) with appreciable recyclability up to six cycles, external base free, Oxalic acid as inexpensive and safer in situ C1 source and vast substrate scope are some remarkable features of the present protocol. Furthermore, we scale up the present reaction up to 1.5 gram.