Ethics Approval Study On The Glucose Regulating Function Of Kudzu Resistant Starch Combined With Probiotics

Type 2 Diabetes Mellitus (T2DM) is a multifaceted metabolic disorder whose current treatments are limited by side effects and potential drug resistance. Recent studies highlight the gut microbiota’s role in T2DM, with modulation via diet or probiotics showing potential for glycemic control. Kudzu resistant starch (KRS) and Bifidobacterium adolescentis are promising interventions, but their combined effects remain unexplored. This study investigates the synergistic effects of KRS and Bifidobacterium adolescentis TH02767 on glycemic control. In vitro fecal fermentation showed that KRS significantly enriched Bifidobacterium levels. In a T2DM mouse model, both KRS and Bifidobacterium adolescentis TH02767 decreased fasting blood glucose levels and enhanced glucose tolerance individually, and their combined treatment exhibited significantly enhanced therapeutic effects. These findings suggest that KRS and Bifidobacterium adolescentis could be a valuable strategy for developing functional foods targeting T2DM management, warranting further exploration of mechanisms and clinical applications. Keywords : Kudzu Resistant Starch; Bifidobacterium adolescentis; Type 2 Diabetes Mellitus; Gut Microbiota; Glycolipid Metabolism