Piezoredox catalysis exploits the unique properties of piezoelectric materials to drive redox reactions under mechanical stress, combining sonochemistry and mechanochemistry with heterogeneous catalysis as an alternative to traditional methods.By utilizing piezoelectric materials that generate localized electric fields upon mechanical activation, this approach facilitates organic transformations without requiring potential bias, heat, or light.This review discusses the fundamentals of piezocatalysis, the organic transformations it enables, and the strategies for selecting efficient piezocatalysts.It also addresses current challenges and future prospects, emphasizing the potential of piezoredox catalysis to advance synthetic methodologies.