Cu2–xO@Ti3C2 Integrated Photothermal Nanofibers with Antibacterial, Anti-Inflammatory, and Hemostatic Properties for Promoting Infected Diabetic Wound Healing

Infected diabetic wounds represent a significant challenge in clinical care due to persistent inflammation and impaired healing. To address these issues, the development of novel wound dressings with both antibacterial and reactive oxygen species (ROS) scavenging properties is essential. Herein, we prepare a novel wound dressing composed of Cu2–xO nanoparticles decorated on Ti3C2 MXene (Cu2–xO@Ti3C2) and integrate it into a poly(vinyl alcohol) (PVA) matrix to form electrospun nanofibers (Cu2–xO@Ti3C2@PVA). Cu2–xO@Ti3C2 exhibits remarkable photothermal conversion efficiency and effective ROS scavenging properties. In vitro experiments demonstrated that Cu2–xO@Ti3C2 effectively kills bacteria upon near-infrared (NIR) irradiation, which can be attributed to the photothermal therapy (PTT) effect of Ti3C2. At the same time, the ROS scavenging abilities of both Ti3C2 and Cu2–xO endow Cu2–xO@Ti3C2 with significant in vitro anti-inflammatory effects. As a promising wound dressing, in vivo studies validated the high efficacy of Cu2–xO@Ti3C2@PVA in promoting hemostasis, exerting antibacterial activity, reducing inflammation, and accelerating the healing process of diabetic wounds. This innovative approach provides a comprehensive solution to the multifaceted challenges of diabetic wound healing and paves the way for improved clinical outcomes.