诱导多能干细胞
生物
重编程
常染色体显性多囊肾病
多囊肾病
干细胞
细胞培养
疾病
细胞生物学
癌症研究
细胞
肾
内科学
遗传学
胚胎干细胞
基因
医学
作者
Lilas Batool,Constanze Raab,Christien Madlen Beez,Andreas Kurtz,Maik Gollasch,Bella Rossbach
标识
DOI:10.1016/j.scr.2023.103071
摘要
Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder of adults, characterized by uncontrolled cysts formation that causes a gradual impairment of kidney function. We generated a human induced pluripotent stem cell (hiPSC) line from the urinary cells of a patient diagnosed with ADPKD using a non-integrating Epi5™ Episomal iPSC reprogramming strategy. Characterization of the cell line was performed regarding their undifferentiated status, differentiation potential, and quality control for karyotypic integrity, identity, and clearance of reprogramming vectors. The newly derived hiPSC line, namely BCRTi007-A, can be used in vitro for disease modeling of ADPKD as well as testing for novel therapeutic approaches.
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