细胞毒性T细胞
癌症研究
黑色素瘤
光动力疗法
雷公藤甲素
光敏剂
细胞凋亡
活性氧
药理学
内质网
谷胱甘肽
材料科学
化学
医学
生物化学
体外
有机化学
酶
作者
Yunan Zhao,Yongwei Gu,Qi Fu,Aixue Li,Xiaomeng Tang,Dan Li,Xin Wu,Jiyong Liu
标识
DOI:10.1016/j.matdes.2023.111860
摘要
Malignant melanoma (MM) is an aggressive and easily metastatic cancer that is poorly responsive to current therapy. The crosstalk between melanoma cells and tumor-associated adipocytes (TAA) plays an important role in the progression of MM, which could be leveraged for anticancer treatment. Here, mature adipocytes (Apo) were engineered for encapsulating a palmitic acid-conjugated triptolide derivative (pTP) and photosensitizer Ce6 (named as pTP-Ce6-Apo), to induce a cytotoxic and photodynamic treatment in malignant melanoma. After para-tumor administration, lipolysis releases pTP and Ce6 that is triggered by intracellular glutathione (GSH) and laser irradiation, respectively, subsequently inducing a variety of pathways, inducing the caspase apoptosis program; generation of reactive oxygen species (ROS), and endoplasmic reticulum (ER) stress. Overall, pTP-Ce6-Apo exhibited excellent antitumor performance and high safety, which is desired for MM therapy.
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