内质网
羧酸酯酶
荧光
未折叠蛋白反应
药品
肝损伤
化学
细胞损伤
细胞生物学
细胞
活体细胞成像
药理学
生物物理学
生物化学
医学
酶
生物
细胞凋亡
物理
量子力学
作者
Lei Feng,Chaoyan Han,Xin Zhao,Xiaokui Huo,Zhenlong Yu,Chao Wang,Jingnan Cui,Xiangge Tian,Xiaochi Ma
摘要
An endoplasmic reticulum targeting NIR fluorescent probe (ERBM) was developed for real-time monitoring of carboxylesterase 1 (CES1) and exhibited excellent ER location in living cell imaging. In addition, ERBM was applied to illustrate the regulation characteristics of CES1 under ER stress and acute liver injury models at the cell and animal level.
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