生物
受体
内生
碳水化合物代谢
新陈代谢
嗅觉系统
神经科学
细胞生物学
生物信息学
内分泌学
生物化学
作者
Zhao Yang,Jie Cheng,Pan Shang,Jing Sun,Xiao Yu
标识
DOI:10.1016/j.tcb.2022.09.005
摘要
Olfactory receptors (ORs) are widely expressed in extra-nasal tissues, where they participate in the regulation of divergent physiological processes. An increasing body of evidence over the past decade has revealed important regulatory roles for extra-nasal ORs in glucose metabolism. Recently, nonodorant endogenous ligands of ORs with metabolic significance have been identified, implying the therapeutic potential of ORs in the treatment of metabolic diseases, such as diabetes and obesity. In this review, we summarize current understanding of the expression patterns and functions of ORs in key tissues involved in glucose metabolism modulation, describe odorant and endogenous OR ligands, explain the biased signaling downstream of ORs, and outline OR therapeutic potential.
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