A Novel Self-Assembled Nanocomposite of Magnetic Graphene Oxide Modified Macroporous Resin for Sensitive Determination of Fluoroquinolones in Environment Water Samples

Abstract In this study, a novel magnetic graphene oxide modified macroporous resin was successfully synthesized via a mechanochemical method and employed as the adsorbent for magnetic solid-phase extraction coupled with high-performance liquid chromatography-fluorescence detection for the determination of trace fluoroquinolones in environmental water samples. Moreover, the magnetic nanocomposite prepared was characterized and the parameters of magnetic solid-phase extraction were optimized. The results indicated that the adsorption mechanism of Fe3O4@GO@MR toward FQs was more consistent with the quasi-second-order kinetic model, with a maximum adsorption capacity of 25.8–37.5 mg/g. Under optimal conditions, the limits of detection and quantification were 4 × 10–4–4 × 10–2 mg/L and 2 × 10–3–9 × 10–2 mg/L, respectively, with good linearity in the range from 5 × 10–4 to 1 mg/L (R2 ≥ 0.9991). The average recovery was between 93.6% and 100.1% with relative standard deviation less than 5.5%. The established method was applied to quantify fluoroquinolones in actual water samples with good accuracy and reliability, providing a serviceable perspective for expanding the trace analysis and detection of fluoroquinolones in complex samples.