Eosinophilic pulmonary complications of dupilumab in 2 patients with asthma and chronic rhinosinusitis with nasal polyps

Severe asthma is a heterogeneous clinical entity composed of multiple different phenotypes. Many patients with moderate to severe asthma have an inflammatory endotype characterized by high levels of TH2-mediated inflammation and elevated levels of IL-4, IL-5, and IL-131 as well as significant peripheral and airway eosinophilia. These patients frequently require treatment with tiotropium, azithromycin, or chronic oral corticosteroids, which can be associated with various long-term side effects.