加药
药效学
病危
药代动力学
医学
药理学
重症监护医学
人口
作者
Jiao Xie,Qianting Yang,Xinyan Han,Yuzhu Dong,Tao Zhang,Youjia Li,Meixi Ji,Chenwei Liu,Yan Cai,Yan Wang
摘要
Differences in pharmacokinetics/pharmacodynamics (PK/PD) target attainment are rarely considered when antifungals are switched in critically ill patients. This study intends to explore whether the antifungal de-escalation treatment strategy and the new intermittent dosing strategy of echinocandins in critically ill patients are able to achieve the corresponding PK/PD targets. The published population PK models of antifungals in critically ill patients and a public data set from the MIMIC-III database ( n = 662) were employed to evaluate PK/PD target attainment of different dosing regimens of antifungals.
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