免疫疗法
胰腺癌
基质
肿瘤微环境
癌症
失调
免疫系统
腺癌
癌症研究
癌症免疫疗法
生物
医学
免疫学
内科学
肠道菌群
免疫组织化学
作者
Robert Harrison Hester,Pawel K. Mazur,Florencia McAllister
标识
DOI:10.1158/1078-0432.ccr-18-0900
摘要
Abstract Immunotherapy has dramatically changed the cancer treatment landscape during the past decade, but very limited efficacy has been reported against pancreatic cancer. Several factors unique to pancreatic cancer may explain the resistance: the well-recognized suppressive elements in the tumor microenvironment, the functional and structural barrier imposed by the stroma components, T-cell exhaustion, the choice of perhaps the wrong immune targets, and microbial factors including gut dysbiosis and the unexpected presence of tumor microbes. Furthermore, we discuss various strategies to overcome these barriers.
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