非对映体
折叠(DSP实现)
手性(物理)
对映体
平面手性
化学
结晶学
分子
分子间力
平面的
组合化学
立体化学
纳米技术
材料科学
对映选择合成
有机化学
催化作用
计算机科学
物理
手征对称破缺
计算机图形学(图像)
量子力学
夸克
Nambu–Jona Lasinio模型
电气工程
工程类
作者
Shengzhou Jin,Jiaying Wang,Yao Tang,Hossein Rouh,Sai Zhang,Ting Xu,Yu Wang,Qingkai Yuan,Daixiang Chen,Daniel K. Unruh,Guigen Li
标识
DOI:10.3389/fchem.2022.860398
摘要
New multilayer 3D chiral molecules have been designed and synthesized asymmetrically through the strategy of center-to-multilayer folding chirality control and double Suzuki couplings. Individual diastereoisomers were readily obtained and separated via flash column chromatography. The key diastereoisomer was further converted into corresponding enantiomers. These enantiomers possess electron-deficient aromatic bridges layered with top and bottom aromatic scaffolds. X-ray structural analysis has unambiguously confirmed the configuration, and intermolecular packing results in regular planar patterns in solid crystals. The synthesis was achieved in a total of ten steps starting from commercially available starting materials.
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