材料科学
模拟体液
阳极氧化
陶瓷
复合数
复合材料
镁
纳米-
成骨细胞
化学工程
扫描电子显微镜
铝
冶金
化学
工程类
生物化学
体外
作者
Vida Khalili,Christina Sengstock,Yordan Kalchev,Janine Pfetzing‐Micklich,Jan Frenzel
标识
DOI:10.1016/j.surfcoat.2022.128730
摘要
The release of Mg ions from Mg-based implants during biodegradation can promote bone repair through osteoblast migration. However, the high pH values (alkaline stresses) associated with this process can be harmful for osteoblasts. Therefore, surface modifications are required which allow to adjust the Mg ion concentration within a tolerable range. The present work investigates the effect of anodizing of magnesium/hydroxyapatite metal matrix nano composites (Mg/HA-ncomposites) on micromechanical behavior and on biological properties. The results will be implemented into a design strategy for improved Mg/HA-ncomposites. The HIPed Mg/HA-ncomposites with varied content of nano hydroxyapatite (n-HA) particles (0, 0.75, 1.8, and 3 wt%) were anodized in a 6 M KOH solution at 1.50 V and 50 °C for 2 h to develop magnesium oxide/hydroxyapatite surface ceramic matrix nano-composite (MgO/HA-ncomposite). The specimens were evaluated by immersing the materials into simulated body fluid (SBF), seeding of human mesenchymal stem cells on the surfaces, and performing nano-indentation and nano-scratch tests. The results show that the uniform distribution of 1.8 wt% n-HA particles in the MgO converted layer strengthens its adhesion as compared to the other types of MgO/HA-ncomposites. Furthermore, the cell spreading of human mesenchymal stem cells on the composite of 1.8 wt% n-HA improves after the anodizing process and after a one-day cell culture. In summary, the present combined micromechanical and biological study has shown that the MgO/HA-ncomposite of 1.8 wt% n-HA represents a promising biomaterial for bio-absorbable bone implants and that it outperforms pure Mg-surfaces.
科研通智能强力驱动
Strongly Powered by AbleSci AI