静电纺丝
纳米纤维
己内酯
乳状液
材料科学
化学工程
生物相容性
扫描电子显微镜
接触角
透射电子显微镜
傅里叶变换红外光谱
复合材料
纳米技术
共聚物
聚合物
工程类
冶金
作者
Masoud Norouzi,Laleh Ghasemi‐Mobarakeh,Fabian Itel,Jean Schoeller,Hossein Fashandi,Aurelio Borzì,Antonia Neels,Giuseppino Fortunato,René M. Rossi
出处
期刊:Nanoscale advances
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:4 (13): 2929-2941
被引量:19
摘要
Electrospun nanofibers have shown great potential as drug vehicles and tissue engineering scaffolds. However, the successful encapsulation of multiple hydrophilic/hydrophobic therapeutic compounds is still challenging. Herein, sodium alginate/poly(ε-caprolactone) core/shell nanofibers were fabricated via water-in-oil emulsion electrospinning. The sodium alginate concentration, water-to-oil ratio, and surfactant concentration were optimized for the maximum stability of the emulsion. The results demonstrated that an increasing water-to-oil ratio results in more deviation from Newtonian fluid and leads to a broader distribution of the fibers' diameters. Moreover, increasing poly(ε-caprolactone) concentration increases loss and storage moduli and increases the diameter of the resulting fibers. The nanofibers' characteristics were investigated by scanning electron microscopy, transmission electron microscopy, confocal laser scanning microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and water contact angle measurements. It was observed that using an emulsion composition of 10% (w/v) PCL and a water-to-oil ratio of 0.1 results in smooth, cylindrical, and uniform core/shell nanofibers with PCL in the shell and ALG in the core. The in vitro cell culture study demonstrated the favorable biocompatibility of nanofibers. Overall, this study provides a promising and trustworthy material for biomedical applications.
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