Detection the Sensitivity of the Gastric Cancer Cell Lines to Paclitaxel or Oxaliplatin by MTT Assay

OBJECTIVE:To determine the sensitivity of paclitaxel or oxaliplatin in gastric cancer celllines by MTT assay.METHODS:Two gastric cancer cell lines included MKN45(low degree differentiation)and SGC7901(moderate degree differentiation)were incubated with paclitaxel or oxaliplatin of various concentration.The cytotoxicity was examined by MTT test.RESULTS:Paclitaxel or oxaliplatin had a significant killing effect on human gastric cancer cells in vitro,gastric cancer cell line SGC7901 is more sensitivity to chemotherapy than poorly differentiated gastric cancer cell line MKN45,which is more sensitivity to paclitaxel than oxaliplatin.CONCLUSIONS:The effect of paclitaxel or oxaliplatin on gastric cancer cells was different among 2 celllines.