Effect of Ginger Root Extract on Oxidative Stress of Alzheimer's Disease Rats

The aim of this study was to investigate the effect of ginger root extract on oxidative stress of Alzheimer's disease(AD) rats which was intervened by β-amyloid protein,and to further explore the therapeutic effect and mechanism of ginger extract on AD.60 healthy rats,including half male and half female,were divided into six groups randomly as follows:OP + GRE low dose group(OP + LG),OP + GRE medium dose group(OP + MG),OP + GRE high dose group(OP + HG),SHAM group(SHAM),OP + HupA group(OP + HupA) and OP group(OP).After gavaging corresponding drugs 4 weeks,the oxidative stress parameters and pathologic changes of rats were determined by immunohistochemical method of superoxide dismutase(SOD),catalase(CAT) and Elisa analysis of malondialdehyde(MDA).The positive expression of CAT and SOD were significantly increased in OP+HG and the OP + HupA group,while MDA levels decreased significantly(P 0.05 vs OP).The difference was not significant in OP + LG group and OP + MG group compared with OP group.Hence,it was concluded that the high doses of ginger root extract can improve the expression of SOD and CAT positively and reduce the levels of MDA in the AD rat.