Relationship between TGF-β_1,COLIII,FN and the process and development of radioation fibrosis

Along with the molecular biological technology development,we realize that the key of radioation fibrosis formation is some activited cytokines and their interaction with some cells. Fibroblast is the producer of ECM, and its activation is the main step of fibrosis. In recent studies, transforming growth factor-β_1 (TGF-β_1) is the most important cause for accumulation of ECM and one of the main initiation factors of radiation fibrosis program. COL Ⅲ and FN are important ingredients of ECM, so they also play an important role in the process and development of radioation fibrosis.