A lots of cation in the salt lake were separated by the ion exchange resin separation. The conditions and the chemistry mechanism were studied.The amounts of bromine and iodine of the salt lake were determined by ICP-MS.Detection limits are 0.015μg/g for bromine,0.036μg/g for iodine.the precision of bromine(RSD) is 2.21%—3.64%,and iodine(RSD) is 4.21%—4.88%. The recovery of bromine is 93.6%—100.5%,and iodine is 93.6%—100.5%.The method has a good application prospect.