Estimation of dialysis dose (Kt/V Urea) by online clearance monitoring in hemodialysis patients with end stage of renal disease

Objective To investigate the relationship between dialysis dose measured by online clearance monitoring(OCM)and Kt/V Urea from pre-and post-dialysis blood-urea samples,and set up a prediction rule to estimate spKt/V by OCM.Methods OCM and Kt/V Urea data from 74 hemodialysis patients were measured.The relationship between OCM and Kt/V Urea was analyzed by correlation assay.Clinical parameters were put into the linear regression formula,based on which the prediction rule was calculated to estimate Kt/V Urea by OCM.Results Dialysis dose measured by OCM was lower than Kt/V Urea,and they had close relationship(r=0.690,P0.001).Based on clinical parameters,Kt/V Urea could be calculated by OCM.Conclusion There is a close relationship between OCM and Kt/V Urea.And based on clinical characters,Kt/V Urea could be calculated by OCM.