Tetramethylpyrazine is the effective components from rhizoma chuanxiong,is a amides alkaloid with several bioactivity enamels from total rhizome chuanxiong alkaloids.At present,the study on the therapeutic effects of tetramethylpyrazine injection is continuously developing,and its clinical application is developing rapidly too.The paper gives the summary about the advance in clinical application of tetramethylpyrazine injection.