化学
抗菌剂
细菌
有机化学
分解
氯化物
化学合成
动力学
药物化学
立体化学
体外
生物化学
遗传学
量子力学
生物
物理
作者
Annalisa Tait,Di Bella M,Moreno Bondi,Giampaola Quaglio,U Fabio
出处
期刊:PubMed
日期:1990-06-01
卷期号:45 (6): 617-30
摘要
A series of carbamimidothioic acid phenylmethyl ester salts and their N,N'-tetramethyl derivatives were synthesized, many of which exert an interesting inhibiting action on Gram-positive and Gram-negative bacteria and also on fungi. This activity is noteworthy in view of the large number of strains antagonized; the (3,4,5-trichlorophenyl) methyl ester chloride of carbamimidothioic acid appeared to be the best term of the series. The possible influence on this activity of decomposition kinetics to the corresponding mercapto-derivatives was investigated and compared with that of a series of N,N'-tetramethyl derivatives of previously studied carbamimidothioic acid phenyl ester salts.
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