骨重建
贾纳斯激酶
细胞生物学
促炎细胞因子
兰克尔
骨吸收
秩配基
细胞因子
生物
骨细胞
激酶
受体
破骨细胞
癌症研究
炎症
免疫学
内分泌学
生物化学
激活剂(遗传学)
作者
Nicola Maruotti,Addolorata Corrado,Cinzia Rotondo,Francesco Paolo Cantatore
摘要
Abstract Janus kinases (JAKs) play a pleiotropic role in several important physiological processes, such as cell maturation, cell proliferation, and cell death, via providing transmission signals from several molecules, such as cytokines, interferons, hormones, and growth factors, to the nucleus. Bone physiology and remodeling are markedly influenced by proinflammatory cytokines. Among them, interleukin‐1 (IL‐1) and IL‐6 are considered potent stimulator of bone resorption. Several cytokine receptors, such as IL‐6 receptors, are characterized by tyrosine kinases of the JAK family associated with their intracellular domains. There is an emerging interest in the effects of JAKs inhibition on the cells involved in bone remodeling. JAK inhibitors represent a new class of molecules involved in the therapy of numerous immune‐mediated inflammatory diseases. In this review, we want to focus on the role of JAKs inhibitors on bone remodeling and on RANKL‐RANK‐OPG signal and inflammatory cytokines which are involved in the regulation of bone cells, such as osteoblasts and osteoclasts.
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