P3‐596: ASSOCIATION OF BDNF AND APOE POLYMORPHISMS IN PRACTITIONERS OF COGNITIVE TRAINING ALLIED TO PHYSICAL ACTIVITY IN AN INLAND TOWN OF BRAZIL

Physical activity (PA) and cognitive training (CT) are low-cost cognitive performance improvement strategies that can be performed as a group and a great option for dementia prevention in underdeveloped countries1. The genetic characteristics may influence the performance in these activities, being evidenced by the genetic polymorphisms2. The objective was to associate BDNF and APOE polymorphisms with the cognitive performance, memory complaint and physical activity level of the elderly before and after three months of CT combined with PA. 42 subjects (50-80 years old) were randomized into two groups: cognitive training and physical activity (CTPA) and control group (CG). We collected demographic data and MoCA, Memory Complaint Scale and Modified Beaeck Questionnaire for Older Adults (MBQOA) for the level of physical activity before and after training. The samples were genotyped by RT-PCR. The mean age of the CTPA group was 63.1 (SD = 6.0) years, 12.3 (SD = 3.6) years of study on average, 45.8% hypertensive, 20.8% diabetic, 33.3% with metabolic syndrome, 37.5% presented ε4 allele of APOE and 33.3% had the BDNF Met allele. The control group had 65.2 (SD = 6.3) years on average, 11.3 (SD = 2.9) years of study, 44.4% hypertensive patients, no diabetics, 55.6% had metabolic syndrome, 33.3% had APOE ε4 allele and 27.8% Met allele of BDNF. In the CTPA group individuals with ε4 had lower baseline scores for MoCA and MBQOA (p <0.05). There was also a worse performance of the MoCA in the baseline (Δ = 3.27 points) and after the training (Δ = 1.98 points) in the group with the ε4 allele. Those with Met allele showed a lower level of PA before (Δ = 2.31 points) and after training (Δ = 0.60 points). In the baseline individuals with Met allele presented more memory complaint (p <0.05). The CG presented no differences. There was an association between APOE and BDNF polymorphisms in the baseline. For both groups there was clinical improvement of the training, but those who presented the polymorphic allele started with a worse performance. 1. https://doi.org/10.1038/s41582-018-0070-3 2. https://doi.org/10.1001/jamaneurol.2017.4365