自愈水凝胶
生物相容性
合理设计
纳米技术
药物输送
生物分子
癌症治疗
材料科学
天然聚合物
超分子化学
聚合物
计算机科学
化学
分子
癌症
高分子化学
有机化学
生物
复合材料
冶金
遗传学
作者
Yanyu Zhang,Yishun Huang
标识
DOI:10.3389/fchem.2020.615665
摘要
Hydrogels are polymeric three-dimensional network structures with high water content. Due to their superior biocompatibility and low toxicity, hydrogels play a significant role in the biomedical fields. Hydrogels are categorized by the composition from natural polymers to synthetic polymers. To meet the complicated situation in the biomedical applications, suitable host–guest supramolecular interactions are rationally selected. This review will have an introduction of hydrogel classification based on the formulation molecules, and then a discussion over the rational design of the intelligent hydrogel to the environmental stimuli such as temperature, irradiation, pH, and targeted biomolecules. Further, the applications of rationally designed smart hydrogels in the biomedical field will be presented, such as tissue repair, drug delivery, and cancer therapy. Finally, the perspectives and the challenges of smart hydrogels will be outlined.
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