In recent years, the treatment concept of retinoblastoma has changed from focusing on saving children's life to preserving the eyeballs and useful visual function. As a promising way to retain the eyeball, the application of vitrectomy in patients with retinoblastoma has long been debated. In view of the special anatomical structure of eyes and the biological characteristics of retinoblastoma cells, retinoblastoma is always prone to recurrence and metastasis after vitrectomy. Therefore, vitrectomy could hardly be a routine treatment and it should be used in retinoblastoma patients cautiously. (Chin J Ophthalmol, 2018, 54: 649-651).近年来视网膜母细胞瘤(RB)的治疗理念已从关注保护患者的生命转变为尽可能保留患者的眼球和有用视功能。玻璃体切除术作为一种保留眼球的治疗方式,是否可以应用于RB的治疗一直存在很大争议。鉴于眼球特殊的解剖结构及RB细胞的生物学特性,本文通过分析玻璃体切除术治疗RB存在的问题以及术后复发性RB的组织病理学改变,指出RB患者进行玻璃体切除术存在较高的肿瘤复发及转移风险,玻璃体切除术不宜作为RB的常规治疗方式,应审慎选择玻璃体切除术治疗RB。(中华眼科杂志,2018,54:649-651).