免疫监视
嵌合抗原受体
免疫疗法
细胞毒性T细胞
免疫学
细胞疗法
癌症研究
免疫系统
癌症免疫疗法
医学
干细胞
生物
细胞生物学
生物化学
体外
作者
María Dolores Corral Sánchez,Lucía Fernández Casanova,Antonio Pérez‐Martínez
标识
DOI:10.1016/j.medcle.2019.08.004
摘要
Children and adolescents suffering from refractory leukaemia, relapse after stem cell transplantation, solid metastatic tumour or refractory to conventional treatments still condition a dismal prognosis. The critical role of the immune system in the immunosurveillance of cancer is becoming relevant with the development of new treatments such as the checkpoint inhibitor drugs and genetic modified T lymphocytes, tisagenlecleucel or axicabtagene ciloleucel. In addition, other immunotherapies are being developed such as cell therapy with natural killer (NK) lymphocytes. The rapid and potent cytotoxic activity of NK cells respecting healthy cells and the possibility of expansion, manipulating them and combining them with other treatments, make these cells a powerful therapeutic tool to be developed, with a very high safety profile. Furthermore, new strategies are being developed to increase the therapeutic benefit of NK cells such as genetic manipulation for the expression of chimeric antigen receptors.
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