Unravelling the Central Dogma of Biology in an active way: a case study

In this paper, we describe a dynamic-model as a strategy to teach DNA transcription and translation in an active way. This activity aims to provide learning beyond memorisation through the simulation of molecular processes, stimulating the elaboration of questions and hypotheses by students. The dynamic consists of four steps, starting with different problem situations which provide a context and encouragement to start the activity. The next steps connect these problems with DNA transcription and translation, requiring the active participation of students to simulate these processes through a construction of a model based on an iron board and representations of cellular structures, enzymes and genetic sequences fixed in magnets. An implementation experience of this dynamic, applied to 21 undergraduate veterinary students at a public university in the city of Curitiba, Paraná State, Brazil, is also described. Data from pre and post-questionnaires suggest knowledge about DNA transcription and translation was improved and some previous mistakes were clarified. Among the positive aspects that were cited by the students, the words visualisation and playful were more frequent, which reflect the didactic aspects of the dynamic. Some points of attention are discussed throughout the paper, as well as educational implications associated with the material and its potential to promote active learning.