丙基硫氧嘧啶
医学
酒精性肝炎
内科学
胃肠病学
安慰剂
双盲
入射(几何)
急性肝炎
肝炎
酒精性肝病
肝硬化
甲状腺
病理
替代医学
物理
光学
作者
Pierre Hallé,Pierre Paré,Elaine M. Kaptein,Gary C. Kanel,Allan G. Redeker,Telfer B. Reynolds
标识
DOI:10.1016/s0016-5085(82)80257-6
摘要
Sixty-seven patients entered a double-blind, controlled trial to evaluate the efficacy of propylthiouracil treatment in severe alcoholic hepatitis. Twenty-three percent (7 of 31) given propylthiouracil and 19% (7 of 36) given placebo died during the 6-wk study. Propylthiouracil treatment did not reduce the frequency and incidence of complications in alcoholic hepatitis, but induced hypothyroidism in 4 patients. Treatment produced no beneficial effect on any of the hepatic biochemical tests. We were unable to show any beneficial effect of propylthiouracil treatment on morbidity and mortality in patients with severe acute alcoholic hepatitis.
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