环糊精
化学
结合常数
超分子化学
循环伏安法
配合物的稳定常数
质子核磁共振
结晶学
物理化学
DNA
分析化学(期刊)
分子
电化学
立体化学
有机化学
水溶液
结合位点
生物化学
电极
作者
K. Srinivasan,K. Sivakumar,T. Stalin
标识
DOI:10.1016/j.carbpol.2014.07.062
摘要
The formation of supramolecular host-guest inclusion complex of 2,6-Dinitroaniline (2,6-DNA) with nano-hydrophobic cavity of β-cyclodextrin (β-CD) in solution phase were studied by UV-visible spectrophotometer and electrochemical method (cyclic voltammetry, CV). The prototropic behaviors of 2,6-DNA with and without β-CD and the ground state acidity constant (pKa) of host-guest inclusion complex (2,6-DNA-β-CD) was studied by Spectrophotometrically. The binding constant of inclusion complex at 303 K was calculated using Benesi–Hildebrand plot and thermodynamic parameter (ΔG) were also calculated. The solid inclusion complex formation between β-CD and 2,6-DNA was confirmed by 1H NMR, FT-IR, XRD and SEM analysis. The β-CD:2,6-DNA inclusion complex obtained by molecular docking studies is in good correlation with the results obtained through experimental methods.
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