木犀草素
紫杉醇
芹菜素
山奈酚
染料木素
柚皮苷
细胞生长
药理学
细胞毒性
槲皮素
卵巢癌
化学
芦丁
类黄酮
生物化学
生物
癌症
抗氧化剂
体外
医学
内科学
内分泌学
色谱法
作者
Haitao Luo,Bing-Hua Jiang,Samuel T. King,Yi Charlie Chen
标识
DOI:10.1080/01635580802100851
摘要
Dietary flavonoids have been shown to be protective against various types of cancers. Here we studied the effects of 12 different flavonoids and other substances on cell proliferation and VEGF expression in human ovarian cancer cells, OVCAR-3. Cell growth was determined to pinpoint the best time for drug treatment. By LDH assay, no cytotoxicity was observed for OVCAR-3 cells with all 12 chemicals except mevinolin. Six flavonoids, including apigenin, taxifolin, luteolin, quercetin, genistein, and kaempferol, were shown to inhibit the ovarian cancer cell growth in a dose-dependent manner. From both RT-qPCR and ELISA results, all flavonoids have shown varied degrees of inhibition in VEGF expression. Taxifolin and naringin showed the least inhibition effect. They both lack a double bond in the second ring structure that may be important in inhibiting VEGF expression. The rank order of VEGF protein secretion inhibitory potency was genistein > kaempferol > apigenin > quercetin > tocopherol > luteolin > cisplatin > rutin > naringin > taxifolin. Genistein, quercetin, and luteolin have shown strong inhibition to cell proliferation and VEGF expression of human ovarian cancer cells, and they show promising in the prevention of ovarian cancers.
科研通智能强力驱动
Strongly Powered by AbleSci AI