Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G‐Quadruplex DNA

Abstract Lighting up : A G‐quadruplex‐specific fluorescent probe was designed combining the specificity of the pyridodicarboxamide motif for guanine quadruplexes and the fluorescence properties of thiazole orange. While the assembly of the two partners through a flexible linker leads to a nonselective probe, merging them in a single, rigid scaffold leads to a dye that elicits the properties required for G‐quadruplex sensing. magnified image