Synthesis and DNA‐binding properties of 1,10‐phenanthroline analogues as intercalating‐crosslinkers

Abstract magnified image We synthesized a series of bis(bromomethyl)‐1,10‐phenanthrolines as novel anticancer lead compounds and examined their DNA‐binding properties. 5,6‐Bis(bromomethyl)‐1,10‐phenanthroline showed DNA intercalating activity and DNA crosslinking activity, furthermore it is stable in aqueous solution.