Comparison of the Effects on Meniere's Symptoms and Medication Compliance between Isosorbid-liquid and Isosorbid-jelly

Most patients with Meniere's disease can be successfully treated with medication. In Japan, since the 1980's we have usually used osmotic diuretics, such as Isosorbide-liquid to control the inner ear endolymphatic hydrops. We have, however, had problems in that Meniere's patients sometimes complain of the tough regimen involving taking Isosorbide-liquid on a daily basis. Recently, Isosorbide-jelly has been developed to improve the medication compliance for patients with Meniere's disease. In the present study, we examined differences between the effects of Isosorbide-liquid and Isosorbide-jelly on hearing and vertigo. We also compared the medication compliance of Isosorbide-liquid with that of Isosorbide-jelly. There were no significant differences in hearing level and vertigo frequency in Meniere's patients before and after Isosorbide-liquid was changed to Isosorbide-jelly. Regarding medication compliance, we should consider which Isosorbide-type we use for each patient on an individual basis.