Angiotensin-Converting–Enzyme Inhibitors for Impaired Glucose Tolerance — Is There Still Hope?

In our increasingly sedentary society, the rates of overnutrition, the metabolic syndrome, and frank diabetes mellitus are rising at an alarming rate.1 Once diabetes has developed, the risks of cardiovascular and renal disease are markedly increased.2 Given the immense costs of diabetes — both personal and economic — considerable attention has been focused on identifying effective strategies to prevent or delay its onset in people at high risk.The benefits of diet and exercise in reducing the risk of diabetes are well accepted. Numerous observational studies have documented that both adiposity and physical inactivity are strong independent risk factors for . . .