果糖
脂肪变性
内科学
内分泌学
干酪乳杆菌
脂肪肝
高果糖玉米糖浆
肠道菌群
化学
生物
医学
生物化学
疾病
发酵
作者
Sabine Wagnerberger,Astrid Spruss,Giridhar Kanuri,Carolin Stahl,Markus Schröder,Walter Vetter,Stephan C. Bischoff,Ina Bergheim
标识
DOI:10.1016/j.jnutbio.2012.01.014
摘要
To test the hypothesis that Lactobacillus casei Shirota (Lcs) protects against the onset of non-alcoholic fatty liver disease (NAFLD) in a mouse model of fructose-induced steatosis, C57BL/6J mice were either fed tap water or 30% fructose solution +/- Lcs for 8 weeks. Chronic consumption of 30% fructose solution led to a significant increase in hepatic steatosis as well as plasma alanine-aminotransferase (ALT) levels, which was attenuated by treatment with Lcs. Protein levels of the tight junction protein occludin were found to be markedly lower in both fructose treated groups in the duodenum, whereas microbiota composition in this part of the intestine was not affected. Lcs treatment markedly attenuated the activation of the Toll-like receptor (TLR) 4 signalling cascade found in the livers of mice only treated with fructose. Moreover, in livers of fructose fed mice treated with Lcs peroxisome proliferator-activated receptor (PPAR)-γ activity was markedly higher than in mice only fed fructose. Taken together, the results of the present study suggest that the dietary intake of Lcs protects against the onset of fructose-induced NAFLD through mechanisms involving an attenuation of the TLR-4-signalling cascade in the liver.
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