丹参
细胞凋亡
A549电池
肺癌
癌症研究
转移
体内
癌细胞
癌症
医学
化学
生物
病理
内科学
生物化学
中医药
替代医学
生物技术
作者
Ching‐Yuan Wu,Yao‐Hsu Yang,Yang-Hua Lin,Geng‐He Chang,Ming‐Shao Tsai,Cheng‐Ming Hsu,Reming-Albert Yeh,Li-Hsin Shu,Yu‐Ching Cheng,Hung-Te Liu
标识
DOI:10.1016/j.biopha.2021.111585
摘要
Danshen (Salvia miltiorrhiza Bunge) is broadly utilized in traditional Chinese medicine for lung cancer. However, it’s exact effort and mechanism on lung cancer is fully unclear. In this study, we found that dihydroisotanshinone I (DT), a pure compound extracted from danshen, can inhibit the growth of A549 cells and H460 cells. DT also induced apoptosis and ferroptosis in these lung cancer cells. DT also blocking the protein expression of GPX4 (Glutathione peroxidase 4). For in vivo study, DT treatment can inhibit metastasis of A549 cells in the nude mice model without adverse effects on mice. In conclusion, DT inhibited the growth of lung cancer cells through apoptosis and ferroptosis and inhibited metastasis of A549 cells in the nude mice model. Further studies are warranted to validate the findings of this study.
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