蛋白酵素
蛋白酶
化学
丝氨酸蛋白酶
酶
蛋白酶抑制剂(药理学)
蛋白水解酶
半胱氨酸蛋白酶
生物化学
蛋白质水解
作者
Jie Zhang,Xi Yang,Youshan Li
出处
期刊:Chinese Journal of Biotechnology
日期:2021-02-01
卷期号:37 (2): 561-579
标识
DOI:10.13345/j.cjb.200579
摘要
Proteases are widely found in organisms participating in the decomposition of proteins to maintain the organisms' normal life activities. Protease inhibitors regulate the activities of target proteases by binding to their active sites, thereby affecting protein metabolism. The key amino acid mutations in proteases and protease inhibitors can affect their physiological functions, stability, catalytic activity, and inhibition specificity. More active, stable, specific, environmentally friendly and cheap proteases and protease inhibitors might be obtained by excavating various natural mutants of proteases and protease inhibitors, analyzing their key active sites by using protein engineering methods. Here, we review the studies on proteases' key active sites and protease inhibitors to deepen the understanding of the active mechanism of proteases and their inhibitors.
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