医学
免疫疗法
免疫系统
癌症免疫疗法
癌症
临床试验
氟脱氧葡萄糖
正电子发射断层摄影术
免疫学
肿瘤科
内科学
放射科
作者
Osigbemhe Iyalomhe,Michael D. Farwell
标识
DOI:10.1016/j.rcl.2021.05.010
摘要
Fluorodeoxyglucose (FDG) PET/CT is sensitive to metabolic, immune-related, and structural changes that can occur in tumors in cancer immunotherapy. Unique mechanisms of immune checkpoint inhibitors (ICIs) occasionally make response evaluation challenging, because tumors and inflammatory changes are both FDG avid. These response patterns and sequelae of ICI immunotherapy, such as immune-related adverse events, are discussed. Immune-specific PET imaging probes at preclinical stage or in early clinical trials, which may help guide clinical management of cancer patients treated with immunotherapy and likely have applications outside of oncology for other diseases in which the immune system plays a role, are reviewed.
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