The article discusses the phenomenon of neuroplasticity and itsfeatures after stroke. The main methods for studying processes of reorganization and plastic changes in the central nervous system are described. Particular attention is paid to the factors determining post-stroke structural and functional reorganization, time parameters starting with the onset of stroke, and stages of post-stroke plastic reorganization; as well as to the afferent andefferent components of neuroplasticity that are closely interrelated. Various aspects of structural and functional reorganization both in the early ontogeny and in the acute and subacute period after stroke are considered. The role and significance of activation patterns in both cerebral hemispheres in recovery of impaired functions after stroke are discussed. The dynamism of neuroplasticity processes and their significance for the poststroke rehabilitation period are emphasized.