细胞毒性
磷酸盐
平衡
矿化(土壤科学)
细胞生物学
钙化
化学
细胞毒性T细胞
生物
生物化学
内科学
医学
生态学
土壤水分
体外
作者
R. Todd Alexander,Nicholas Debiec,Mohammad S. Razzaque,Ping He
出处
期刊:Iubmb Life
[Wiley]
日期:2021-10-22
卷期号:74 (1): 117-124
被引量:7
摘要
Phosphate, an essential nutrient, is available in organic and inorganic forms. The balance of phosphate is central for cellular homeostasis through the genomic roles of DNA and RNA synthesis and cell signaling processes. Therefore, an imbalance of this nutrient, manifested, either as a deficiency or excess in phosphate levels, can result in pathology, ranging from cytotoxicity to musculoskeletal defects. Inorganic phosphate (Pi) overdosing can result in a wide spectrum of cytotoxicity processes, as noted in both animal models and human studies. These include rewired cell signaling pathways, impaired bone mineralization, infertility, premature aging, vascular calcification, and renal dysfunction. This article briefly reviews the regulation of phosphate homeostasis and elaborates on cytotoxic effects of excessive Pi, as documented in cell-based models.
科研通智能强力驱动
Strongly Powered by AbleSci AI