红曲霉
紫色红曲霉
生物
非酒精性脂肪肝
脂肪肝
脂质代谢
胆固醇7α羟化酶
内科学
胆固醇
内分泌学
生物化学
医学
发酵
疾病
作者
Cui-Zhu Zhao,Wei Jiang,Yan Zhu,Chong‐Zhi Wang,Weihong Zhong,Guang Wu,Jie Chen,Mei-Ning Zhu,Qilin Wu,Xiaolang Du,Yingying Luo,Min Li,Hongling Wang,Hui Zhao,Qinge Ma,Guoyue Zhong,Rongrui Wei
标识
DOI:10.1016/j.jep.2021.114922
摘要
Hepatocyte lipid accumulation is the main feature in the early stage of nonalcoholic fatty liver disease (NAFLD). Highland barley Monascus purpureus Went (HBMPW), a fermentation product of Hordeum vulgare Linn. var. nudum Hook. f. has traditionally been used as fermented foods in Tibet with the effect of reducing blood lipid in folk medicine.This study investigated the protective effects and molecular mechanism of highland barley Monascus purpureus Went extract (HBMPWE) on NAFLD in syrian golden hamster fed with high-fat, high-fructose, high-cholesterol diet (HFFCD).HFFCD-induced NAFLD golden hamster model was established and treated with HBMPWE. Liver index, biochemical index, and hematoxylin and eosin (HE) staining were observed. Liver metabolomics and western blot analysis were employed.Our study found that HBMPWE ameliorated HFFCD induced dyslipidemia, weight gain and elevated the liver index. In addition, HBMPWE treatment significantly attenuated lipid accumulation in the liver and modulated lipid metabolism (sphingolipid, glycerophospholipid). Our data demonstrated that HBMPWE not only regulated the expression of proteins related to fatty acid synthesis and decomposition (SREBP-1/ACC/FAS/AceS1, PPARα/ACSL/CPT1/ACOX1), but also regulated the expression of proteins related to cholesterol synthesis and clearance (HMGCR, LDLR, CYP7A1).HBMPWE improved NAFLD through multiple pathways and multiple targets in body metabolism and could be used as a functional food to treat NAFLD and other lipid metabolic disorders.
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