光热治疗
免疫疗法
生物医学中的光声成像
免疫原性
背向效应
化学
癌症研究
显像剂
材料科学
癌症
纳米技术
医学
抗原
体内
免疫学
生物
内科学
生物技术
物理
光学
作者
Dingyuan Yan,Miao Wang,Qian Wu,Niu Niu,Meng Li,Ruixiang Song,Jie Rao,Miaomiao Kang,Zhijun Zhang,Feifan Zhou,Dong Wang,Ben Zhong Tang
标识
DOI:10.1002/anie.202202614
摘要
Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation-induced emission, namely TPA-BT-DPTQ, was designed and prepared based on benzo[c]thiophene unit as a building block; it can be used for simultaneous fluorescence imaging (FLI) in the second near-infrared (NIR-II) window, photoacoustic imaging (PAI), photothermal imaging (PTI), and thermal eradication of tumors. Further experiments validate that photothermal therapy (PTT) mediated by TPA-BT-DPTQ nanoparticles not only destroys the primary tumor but also enhances immunogenicity for further suppressing the growth of tumors at distant sites. Furthermore, PTT combining a programmed death-ligand 1 (PD-L1) antibody prevents the metastasis and recurrence of cancer by potentiating the effect of immunotherapy.
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