背景(考古学)
生物
细胞生物学
网状结缔组织
病毒学
病毒进入
T细胞
细胞融合
细胞
抗原
细胞迁移
人类免疫缺陷病毒(HIV)
免疫学
病毒
免疫系统
病毒复制
遗传学
解剖
古生物学
作者
Paúl López,Oluwaseun Ajibola,Amélie Pagliuzza,Romaniya Zayats,Wan Hon Koh,Alon Herschhorn,Nicolas Chomont,Thomas T. Murooka
出处
期刊:Cell Reports
[Elsevier]
日期:2022-02-01
卷期号:38 (8): 110406-110406
被引量:4
标识
DOI:10.1016/j.celrep.2022.110406
摘要
T cells actively migrate along reticular networks within lymphoid organs in search for cognate antigen, but how these behaviors impact HIV entry and infection is unclear. Here, we show that migratory T cells in 3D collagen matrix display significantly enhanced infection and integration by cell-free R5-tropic lab adapted and transmitted/founder molecular HIV clones in the absence of exogenous cytokines or cationic polymers. Using two different collagen matrices that either support or restrict T cell migration, we observe high levels of HIV fusion in migratory T cells, whereas non-motile T cells display low viral entry and integration. Motile T cells were less sensitive to combination antiretroviral drugs and were able to freely migrate into regions with high HIV densities, resulting in high infection rates. Together, our studies indicate that the environmental context in which initial HIV-T cell encounters occur modulates HIV-1 entry and integration efficiencies.
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