红豆杉
基因簇
生物
基因组
基因
计算生物学
遗传学
生物合成
植物
作者
Xingyao Xiong,Junbo Gou,Qinggang Liao,Yanlin Liu,Qian Zhou,Guoan Bi,Chong Li,Ran Du,Xiaotong Wang,Tianshu Sun,Lvjun Guo,Haifei Liang,Pengjun Lu,Yaoyao Wu,Zhonghua Zhang,Dae‐Kyun Ro,Yi Shang,Sanwen Huang,Jianbin Yan
标识
DOI:10.1101/2021.04.29.441981
摘要
Abstract The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are available for comprehensively elucidating the paclitaxel biosynthesis pathway. We have completed a chromosome-level genome of Taxus chinensis var. mairei with a total length of 10.23 Gb. Taxus shared an ancestral whole-genome duplication with the coniferophyte lineage and underwent distinct transposon evolution. We discovered a unique physical and functional grouping of CYP725As (cytochrome P450) in the Taxus genome for paclitaxel biosynthesis. We also identified a gene cluster in the taxadiene biosynthesis, which was mainly formed by gene duplications. This study will facilitate the elucidation of paclitaxel biosynthesis and unleash the biotechnological potential of Taxus. One Sentence Summary A chromosome-level genome assembly of Taxus chinensis var. mairei uncovers its unique genome evolution process and genetic architectures for the paclitaxel biosynthesis pathway.
科研通智能强力驱动
Strongly Powered by AbleSci AI